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Bootstrap is based on rows (to a significant degree). Early builds of Respondr use rows instead of columns. This approach works really well for portlets of approximately uniform height; but the existing stable of Apereo portlets are not very uniform. Portlets of mixed heights lead to wasted screen real estate, in the form of large empty area beneath shorter portlets.
We expect that newer builds of Respondr – starting quite soon – will feature Respondr currently features one, "main" row which will contain columns of portlets (just like Universality). In the future, it may be possible for schools that implement Respondr to choose...
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We'll probably look very closely at porting over the Customize drawer (from Universality) as-is (or nearly), since that approach may allow us to support the most features the fastest. But there could be aspects of how personalization was implemented in Universality that don't make complete sense in Respondr, so perhaps some or all of the Customize drawer will be re-designed... even before uP 4.1 is released.
The University of Wisconsin-Madison is pursuing a pretty different idea of how personalization will work in their implementation of Respondr, adding a concept of Favorites that replaces the experience (and is under the hood built on) traditional Layout. Instead of "Add to Layout", with Favorites you "Add to Favorites". This isn't entirely baked yet.